Rega's headquarters is situated to the north-east of Zurich-Kloten Airport and has direct access to the runways. From here, Rega organises assistance from the air around the clock and closely monitors all the missions being carried out within Switzerland and worldwide.

The building houses a hangar for the three ambulance jets, a maintenance works for the helicopters and ambulance jets, the Operations Centre, recreation rooms for the flight crew on stand-by duty, administrative offices, training and lecture rooms, a cafeteria for the approximately 150 employees working here and a large materials store.

While the ambulance jets take off directly from the Rega Centre every day to destinations all over the globe, the rescue helicopters only come to the Rega Centre for major maintenance work and servicing. Rescue missions in the Zurich region are performed from Rega's Zurich base in the nearby suburb of Dübendorf.